**Hallmarks of Cancer** (Verse 1) In the quiet cells where chaos begins, A rogue signal calls, let the battle spin, **Sustained proliferative signalling** leads the way, Uncontrolled growth, night and day. (Chorus) Hallmarks of cancer, where dark secrets lie, Sustained growth, **immortality**, reaching for the sky, **Evading growth suppressors**, resisting death’s call, **Invasion and metastasis**, they conquer all. (Verse 2) Suppressors evaded, they hide in the night, **Tumour suppressor genes** lost from sight, **Resisting cell death**, they refuse to fall, Dormant yet alive, standing tall. (Chorus) **Hallmarks of cancer**, where dark secrets lie, Sustained growth, **immortality**, reaching for the sky, **Evading growth suppressors**, resisting death’s call, **Invasion and metastasis**, they conquer all. (Rap) Six hallmarks, listen close, let me lay it out, What cancer’s all about, no room for doubt: **Sustained proliferative signalling** – growth won’t quit, **Evading growth suppressors** – they’re too slick, **Resisting cell death** – apoptosis denied, **Enabling replicative immortality** – endless divide, **Inducing angiogenesis** – blood vessels they grow, **Activating invasion and metastasis** – spreading their woe. (Bridge) **Enabling replicative immortality**, endless divide, Telomeres preserved, no limit to their stride, **Inducing angiogenesis**, new vessels they weave, A blood supply secured, they continue to deceive. (Verse 3) **Activating invasion and metastasis**, breaking through the wall, Spreading to new lands, heed the call, Different types of invasion, each cancer its own, Metastatic spread, new seeds are sown. (Chorus) **Hallmarks of cancer**, where dark secrets lie, Sustained growth, **immortality**, reaching for the sky, **Evading growth suppressors**, resisting death’s call, **Invasion and metastasis**, they conquer all. (Outro) Emerging hallmarks, new traits to learn, **Deranged cellular energetics**, energy to burn, **Avoiding immune destruction**, they change and adapt, **Unlocking phenotypic plasticity**, the lines are mapped. **Genome instability**, mutations dance, **Tumour-promoting inflammation**, their deadly romance, In the world of cells, where shadows grow, The **hallmarks of cancer**, forever flow.
