Colorectal cancer, here’s what to know, Epidemiology, risk factors in tow. Genetics, screening, symptoms to show, Early and late management, let’s go. (Chorus) Screen and detect, know the signs, Together we fight, in these times. Knowledge is power, early detect, Colorectal cancer, we’ll protect. Incidence is high, affecting many lives, Risk factors include lifestyle dives. Smoking, alcohol, red meat in line, Obesity, low veggies, cancer's sign. Pathogenesis, from a polyp they grow, Aberrant crypt to neoplasm we know. Stem cells in crypts, they begin, Genetic mutations make cancer win. (Chorus) Screen and detect, know the signs, Together we fight, in these times. Knowledge is power, early detect, Colorectal cancer, we’ll protect. Two pathways to know, adenoma and serrated, Chromosomal instability often stated. APC mutation, RAS activation, Microsatellite instability, genetic foundation. Screening every two years, from age fifty, Immunochemical faecal test, it’s thrifty. Early diagnosis saves lives we see, Less invasive treatment, a better quality. CEA marker, helps in the fight, Other cancers can raise it, keep it in sight. Staging important, TNM we use, From stage I to IV, treatment clues. (Chorus) Screen and detect, know the signs, Together we fight, in these times. Knowledge is power, early detect, Colorectal cancer, we’ll protect. Stage I, surgery might be enough, Stage II, adjuvant therapy if it’s tough. Stage III, chemo comes in play, Stage IV, focus on quality, day by day. Systemic options, many to choose, 5-FU, Oxaliplatin, help us refuse. Bevacizumab for anti-angiogenic, Cetuximab, Panitumumab, EGFR specifics. Immunotherapy, PD-1 blockade, Microsatellite instability, immune aid. Targeted therapy, BRAF mutant fight, Encorafenib, cetuximab, keeping it tight. (Chorus) Screen and detect, know the signs, Together we fight, in these times. Knowledge is power, early detect, Colorectal cancer, we’ll protect. Rectal cancer, risk factors here, Age, diet, obesity, clear. Screen, detect, treat it right, Together we’ll win, in this fight.


