The Signal Spiral

(Intro - hypnotic, building energy) Signaling in cells, electric waves, Messages moving, how they behave. Across the membrane, through the light, Kinases activate the fight. Verse 1 RTKs light the way, growth factors bound to play, Phosphorylation sets the pace, in the cell division race. Insulin comes, glucose streams, PKB fulfills the dreams, Glucose transporters, fat cells feast, energy stored, a metabolic beast. Chorus 1 G-protein spiral, seven helix spin, cAMP rising, let the signaling begin. Ras to MAPKs, phosphorylating more, Gene expression opens up the nuclear door. Verse 2 Cytokines shout, JAKs align, STATs dimerize, it’s a gene-signing time. TGF-β binds, Smads on the move, Into the nucleus, where genes start to groove. Ras gets flipped, GDP's gone, GTP switches, and now Ras is on. RAF to MEK to MAPKs they pass, Growth and survival—transcription at last. Chorus 2 Wnt and Hedgehog, signaling dreams, Frizzled, Dishevelled, β-catenin screams. Patched releases, Smoothened goes, The pathway’s lit, gene expression flows. NF-κB keeps the stress in line, Inflammation, immune response, in time. (Bridge - psychedelic, building intensity) Notch and Delta touch and bind, Cell fate decision, now aligned. Cleavage signals inside the core, Genes turned on, forevermore. Steroid hormones, passing through, Binding DNA, they tell what to do. Cortisol and estrogen reign, Glucocorticoids ease the pain. Verse 3 Insulin knocks, RTK calls, Glycogen synthesis breaks down walls. PKB rises, PIP3's fire, Metabolic flames never tire. MAPK enters the nuclear tide, Activating genes far and wide. Chorus 3 cAMP floods, adenylyl screams, Protein kinase A, fueling dreams. Phosphorylation spreads its wings, Energy rises, the signal sings. Kinase cascades, Ras races fast, Phosphorylation until the last. (Bridge 2 - hypnotic breakdown) Wnt binds Frizzled, β-catenin’s free, Cell development is the key. Patched holds Smoothened, then lets it go, Gli proteins activate, gene transcription flows. Stress comes knocking, NF-κB flies, Inhibitor's gone, inflammation’s on the rise. Verse 4 Glucocorticoids bind, cortisol’s in sight, Receptor complex heads into the light. DNA’s bound, transcription unfolds, The signal’s story, forever told. Chorus 4 (Extended, Outro) G-protein spiral, a cellular dream, Signaling pathways, endless stream. RTK’s, MAPKs, Smads in line, Cell fate decided, signal’s design. From the nucleus to the cytosol core, Gene expression opens the door. (Outro - repetitive and trance-inducing) Signaling waves, moving inside, Genes are expressed, cells collide. Phosphorylation sparks the flame, Cell survival, forever the aim. Signal cascade, forever the flow, Cellular magic, the ultimate show.